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Cervical Cancer

Cervical cancer begins when abnormal cells grow in the cervix — the lower part of the uterus that connects to the vagina. Most cases are linked to certain strains of the human papillomavirus (HPV), a common sexually transmitted infection.

In most people, the immune system clears HPV naturally. However, in a small percentage, the infection persists for years, leading to cellular changes that can develop into cancer.

Cervical cancer is highly preventable through regular screening tests and HPV vaccination. When detected early, it is also highly treatable.

Causes of Cervical Cancer

  • HPV Infection: Persistent infection with high-risk HPV types — especially HPV 16 and HPV 18 — causes about 70% of cervical cancers worldwide.

  • Progression: Most HPV infections resolve naturally within 1–2 years. Long-term infections can cause precancerous lesions, which, if untreated, may develop into cervical cancer.

  • Transmission: HPV spreads through vaginal, anal, or oral sexual contact. Early sexual activity (before 18) and multiple sexual partners increase the risk of acquiring high-risk HPV.

Risk Factors

Changeable Risk Factors:

  • HPV Infection: Persistent infection with high-risk HPV types — especially HPV 16 and HPV 18 — causes about 70% of cervical cancers worldwide.

  • Progression: Most HPV infections resolve naturally within 1–2 years. Long-term infections can cause precancerous lesions, which, if untreated, may develop into cervical cancer.

  • Transmission: HPV spreads through vaginal, anal, or oral sexual contact. Early sexual activity (before 18) and multiple sexual partners increase the risk of acquiring high-risk HPV.

Unchangeable Risk Factors:

  • DES Exposure: If your mother took diethylstilbestrol during pregnancy (1940–1971).

  • Family History: Genetics may play a role.

Symptoms

Early Stage (Often No Symptoms):

  • Watery or bloody vaginal discharge (possibly foul-smelling).

  • Vaginal bleeding after sex, between periods, or after menopause.

  • Pain during intercourse (dyspareunia).

Advanced Stage Symptoms (Spread to Nearby Tissues/Organs):

  • Painful or difficult urination, blood in urine.

  • Rectal bleeding, diarrhea, or pain during bowel movements.

  • Fatigue, weight loss, and appetite loss.

  • Persistent pelvic or abdominal pain.

  • Swelling in the legs.

  • Dull backache.

Seek medical advice if you notice abnormal bleeding, unusual discharge, or persistent pelvic discomfort.

Prevention

HPV Vaccination

  • Gardasil 9 protects against 7 cancer-causing HPV types and 2 wart-causing types.

  • Most effective before sexual activity begins.

Recommended for:

  • Girls and boys aged 11–12 (can start at 9).

  • Catch-up vaccination up to age 26.

  • Some adults aged 27–45 may benefit after consultation.

Dosing:

  • Before age 15 → 2 doses.

  • 15+ or immunocompromised → 3 doses.

Regular Screening

  • Pap Test and/or HPV Test detect abnormal cells early.

  • Start screening in your 20s and follow your doctor’s recommendations.

  • Even vaccinated individuals need screening.

Safe Sexual Practices

  • Use condoms and limit number of sexual partners.

Lifestyle Choices

  • Quit smoking.

  • Maintain a healthy weight.

Treatment Options

Treatment depends on cancer stage, age, overall health, and fertility plans.

1. Surgery

  • Laser Surgery: Burns away cancer cells.

  • Cryosurgery: Freezes and destroys abnormal cells.

  • Hysterectomy: Removes uterus and cervix.

  • Trachelectomy: Removes cervix but preserves uterus.

  • Pelvic Exenteration: Removes reproductive organs and possibly bladder, rectum, or part of the colon if cancer has spread.

2. Radiation Therapy

  • External Beam Radiation (EBRT): High-energy beams target cancer from outside the body.

  • Brachytherapy: Places radiation inside or near the tumor.

3. Chemotherapy

  • Drugs delivered orally or intravenously to kill cancer cells.

  • Often used in cycles and sometimes combined with radiation

4. Targeted Therapy

  • Attacks specific proteins that cancer cells need to grow.

5. Immunotherapy

  • Boosts the immune system to recognize and destroy cancer cells.

6. Clinical Trials

  • Offer access to new and experimental treatments.

Prognosis & Curability

  • Early Stages (Stage I): Highly treatable, often with surgery alone.

  • Advanced Stage (Stage IV): Cure is less likely, but remission is possible with treatments like chemotherapy, radiation, and targeted therapies.

  • Remission: Even after successful treatment, regular follow-up is essential because cancer can return.

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